彭敏博士在免疫代謝和營養(yǎng)信號(hào)轉(zhuǎn)導(dǎo)方面進(jìn)行了深入的研究，發(fā)現(xiàn)多種調(diào)控營養(yǎng)信號(hào)轉(zhuǎn)導(dǎo)的關(guān)鍵分子以及代謝通路調(diào)控免疫細(xì)胞分化的分子機(jī)制，相關(guān)研究成果發(fā)表在Cell、Nature及Science等國際學(xué)術(shù)期刊，并獲得“求是”杰出青年學(xué)者獎(jiǎng)。目前， 彭敏博士致力于使用高通量功能基因組學(xué)技術(shù)系統(tǒng)性地研究T淋巴細(xì)胞增殖分化的調(diào)控機(jī)理以及細(xì)胞代謝調(diào)節(jié)免疫應(yīng)答等的分子機(jī)制，并利用這些分子機(jī)理為免疫相關(guān)疾病的診斷和治療提供新策略和新靶點(diǎn)。

實(shí)驗(yàn)室研究方向：

T cells play essential roles in immune response. We are studying T cells with two directions:

1. Functional genomics in primary T cells

We are applying genome-wide CRISPR/Cas9 screen in primary T cell in vivo to answer fundamental questions in T cell biology, including development, activation, proliferation and differentiation, as well as T cell fitness (e.g. exhaustion) in tumor microenvironment.  Identified novel genes and regulatory circuits have been used to design novel therapies for diseases.

2. Mechanisms of metabolic regulation of T cells

Metabolic reprogramming is a hallmark of T cell activation, but how metabolic pathways regulate T cell function remains poorly understood. We are using mouse models with gain- and loss-of-function of key metabolic enzymes to decipher metabolic regulation T cell, and try to target metabolism to treat immune-related diseases.

參考文獻(xiàn)：

1. Hanfei Zhao, Ying Liu, Lixia Wang, Gang Jin, Xiaocui Zhao, Jing Xu, Guangyue Zhang, Yuying Ma, Na Yin, Min Peng. Genome-wide fitness gene identification reveals Roquin as a potent suppressor of CD8 T cell expansion and anti-tumor immunity. Cell Reports. 2021 Dec 7;37(10):110083.

2. Ke Xu*, Na Yin*, Min Peng, Efstathios G Stamatiades, Sagar Chhangawala, Amy Shyu, Peng Li, Xian Zhang, Mytrang H Do, Kristelle J Capistrano, Chun Chou, Christina S Leslie, Ming O Li. Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses. Immunity. 2021. 54(5):976-87.  

3. Ke Xu, Na Yin, Min Peng, Efstathios G Stamatiades, Amy Shyu, Peng Li, Xian Zhang, Mytrang H Do, Zhaoquan Wang, Kristelle J Capistrano, Chun Chou, Andrew G Levine, Alexander Y Rudensky, Ming O Li. Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity. Science. 2021.371(6527):405-10.

4. Min Peng*, Na Yin*, Sagar Chhangawala, Ke Xu, Christina S. Leslie, Ming O. Li. Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. Science. 2016 Oct 28; 354(6311): 481-484.

Preview in Science, 2016 Oct 28; 354(6311): 419-420. “Warburg meets epigenetics”.

Preview in Dev Cell, 2016 November 7;39: 286-287. “Metabolic Control of Cellular Differentiation”.

Preview in Cell Metab, 2016 November 8; 24: 651-652. “Metabolic Signaling Drives IFN-g”.

5. Min Peng, Na Yin, Ming O. Li. SZT2 dictates GATOR control of mTORC1 signaling. Nature. 2017 Mar 16;543(7645):433-437.

6. Min Peng, Na Yin, Ming O. Li. Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling. Cell. 2014 Sep 25; 159(1): 122-33.

博士后招聘

CAR-T腫瘤治療方向2名：

應(yīng)聘條件：具有免疫學(xué)、分子和細(xì)胞生物學(xué)相關(guān)專業(yè)博士學(xué)位，獲得博士學(xué)位2年以內(nèi)；近期以第一作者身份在國際知名學(xué)術(shù)期刊發(fā)表研究論文，符合清華大學(xué)博士后入站標(biāo)準(zhǔn)；熱愛科研工作，責(zé)任心強(qiáng)，具備團(tuán)隊(duì)合作精神；具備較好的英語溝通、閱讀和寫作能力。

崗位待遇： 崗位待遇按照清華大學(xué)相關(guān)規(guī)定執(zhí)行。課題組將根據(jù)工作情況提供一定生活補(bǔ)助和績(jī)效獎(jiǎng)勵(lì)。另外，根據(jù)本單位相關(guān)規(guī)定，博士后以第一作者、清華大學(xué)為第一單位發(fā)表高水平學(xué)術(shù)期刊可獲得有非常有競(jìng)爭(zhēng)力的績(jī)效獎(jiǎng)勵(lì)（http://postdoctor.tsinghua.edu.cn/）。

申請(qǐng)方式：將簡(jiǎn)歷（包括學(xué)歷和論文發(fā)表情況）、研究自述（研究興趣、成果以及未來職業(yè)規(guī)劃）、及2-3名推薦人的聯(lián)系方式發(fā)至：pengmin@tsinghua.edu.cn；主題標(biāo)明“姓名+應(yīng)聘博士后 “。

信息來源于網(wǎng)絡(luò)，如有變更請(qǐng)以原發(fā)布者為準(zhǔn)。

來源鏈接：

http://www.cls.edu.cn/Careers/Postdoctoral5565.shtml

為防止簡(jiǎn)歷投遞丟失請(qǐng)抄送一份至：boshijob@126.com（郵件標(biāo)題格式：應(yīng)聘職位名稱+姓名+學(xué)歷+專業(yè)+中國博士人才網(wǎng)）