University Grade 7: £29,541 – £36,298 p.a.
Applications are invited for a Postdoctoral Scientist in an exciting new research programme at the WIMM, to discover and develop small molecule inhibitors of mutant RAS for treatment of cancer. This new chemical biology drug discovery programme has co-investigators based at the Research Complex at Harwell (RCaH) and the Department of Chemistry, Oxford, and is funded by a Wellcome Trust Seeding Drug Discovery Initiative.
The specific aim of the project is to develop small-molecule drugs that inhibit protein-protein interactions involving the RAS family of proteins. The project will adopt a highly innovative strategy for identification of drug-like molecules, using an antibody fragment that inhibits RAS-effector protein interaction as a structural template for small molecule drug development.
Candidates will hold a PhD in molecular biology. Experience with recombinant protein production and purification, surface plasmon resonance and ITC together with experience of developing and implementing cell based assays and molecular cloning are essential. Experience with AlphaScreen and other methods for small molecule screening would be advantageous.
Available for 3 years starting 01 September 2013, the post will be based in the laboratory of Professor Terry Rabbitts http://www.imm.ox.ac.uk/wimm-research/molhaem/terry_rabbitts at the Weatherall Institute of Molecular Medicine. Informal enquiries may be made by email, clearly stating the vacancy number, toterence.rabbitts@imm.ox.ac.uk
Applications for this vacancy are to be made online. To apply for this role and for further details, including a job description and selection criteria, please click on the link below:https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=109409
You will be required to upload a CV and supporting statement as part of your online application
The closing date for this position is midday on Friday 30 August 2013.
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