The lab of Chuck Sanders at Vanderbilt University (http://structbio.vanderbilt.edu/sanders) has an opening for a postdoctoral fellow to conduct studies of the structure, folding, and function of the human KCNQ1 potassium channel. KCNQ1 is a critical voltage-gated channel in the cardiac action potential. Mutations in KCNQ1 and its modulatory partner, KCNE1, result in various cardiac arrhythmias, including long QT syndrome and sudden infant death syndrome. Mutations can disrupt normal channel function by disrupting folding, by altering protein structure, or via more subtle affects on channel regulation and mechanism. The long term goal of our studies is to develop a sufficiently robust understanding of the structure, folding, and function of KCNQ1 to be able to accurately predict whether newly discovered mutations are disease-predisposing or not. This will be very important in personalized medicine as personal genome sequencing becomes a routine part of patient healthcare. This multidisciplinary project is being conducted in close collaboration with the labs of Profs. Jens Meiler (computational biology, Vanderbilt)and Alfred George (electrophysiology, Northwestern). We are seeking a highly motivated postdoc who will conduct studies of the folding and/or structure of the KCNQ1 channel and of the KCNQ1/KCNE1 complex. Students with a good publication record and experience in protein biochemisty, biophysics, and/or structural biology are encouraged to apply. Previous postdocs on this project have gone on to faculty positions. Candidates should send a curriculum vita, including contact info for references to: Prof. Charles Sanders, Dept. of Biochemistry and Center for Structural Biology, Vanderbilt University Nashville, Tennessee …
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