MRC Postdoctoral Scientist (CSC 74) : London, United Kingdom

About Us
We are one of three directly funded MRC research institutes and enjoy close links with our partners at Imperial College London and at the Imperial College Healthcare NHS Trust. Based at Hammersmith Hospital our research focuses on strengthening the basic science underpinning our understanding of human diseases and the translation of such high quality research into a clinical setting.

About the Role
A 3-year postdoctoral position is available at Imperial College London and the MRC Clinical Sciences Centre (CSC) to work in the Molecular Systems group headed by Dr Tobias Warnecke. 
The post will be based on the Hammersmith Hospital campus at the CSC, which has first class facilities and provides investigators from clinical and basic science backgrounds with the opportunity to pursue innovative, multidisciplinary research within the established clinical base of Imperial College.

We are looking for an enthusiastic, creative postdoctoral scientist to join a diverse computational/experimental research team that works at the intersection of molecular evolution, systems biology, and (more often than not) epigenetics. Recent questions we have tackled include:

• Can RNA chaperones buffer deleterious mutations (answer: yes! see Rudan et al. 2015 eLife 4:e04745) and how does buffering by chaperones affect the evolution and evolvability of their substrates?
• How does chromatin architecture affect DNA sequence evolution?
• Do different epigenetic marks all come with their own unique mutational burden? (Supek et al. 2014 PLoS Genet 10:e1004585)
• What is the difference between prokaryotic and eukaryotic chromatin and how did complex epigenetic regulation evolve?

About You
You will aim to make a major contribution to our ongoing research program and, in addition, develop and carry out his/her own line of research within the group’s areas of interest and expertise. Candidates keen to mix wet (E. coli, archaea) and dry lab work are particularly encouraged to apply. You must have a strong publication record, excellent verbal and written communication skills, and a track record of addressing scientific problems in an innovative, thoughtful and systematic manner.

If you have a mainly computational background, you should be proficient in at least one programming/scripting language (java, python, etc.) as well as R/matlab and, ideally, have experience in analysing data from high-throughput sequencing experiments (e.g. Chip-Seq, RNA-Seq). If you are from an experimental background, you should have substantive experience in molecular techniques for the manipulation of prokaryotes and, ideally, experience with protein-DNA/RNA interaction assays (e.g. CLIP, ChIP). Whatever your background, a keen interest in evolutionary processes is a must.

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