MRC Postdoctoral Fellow

　　MRC Toxicology Unit, Cambridge

　　£32,236-£39,609

　　Reference: PU16847

　　The Medical Research Council Toxicology Unit is an internationally renowned institution focused on the delivery of field-changing mechanistic insights into toxicology and disease. The Unit is equipped with state-of-the-art facilities including Cryo-EM and offers excellent opportunities for postdoctoral development. The Unit is part of the University of Cambridge; it is currently located at Leicester and will physically relocate to Cambridge in 2020.

　　We are looking to appoint an MRC Postdoctoral Fellow (PF) to work in the laboratory of Prof. Marion MacFarlane to carry out research into the 'Molecular Mechanisms of Cell Death'.

　　Our laboratory is focused on investigating cell death pathways that are regulated in response to members of the TNF cytokine family and agents that trigger mitochondrial-dependent cell death, with a specific emphasis on mechanisms that regulate activation of cell death signalling complexes.

　　The aim of the project is to obtain novel insights on the regulation and 3D molecular architecture of key multiprotein signalling complexes that direct cell death/survival.

　　This is a three year training and development position during which you will receive a range of formal and on-the-job training to ensure you receive the skills relevant to your role and to help support your future career.

　　Applicants must have (or be in the final stages of receiving) a PhD in a relevant discipline and have experience in protein expression/the analysis of protein structure and function. Experience in Cryo-Electron Microscopy/analysis is desirable. The ability to publish high quality research in a peer reviewed journal; to be able to work both independently and as part of a team, together with excellent communication and problem solving skills are required.

　　This post requires you to hold a PhD in a relevant discipline. Whilst we welcome applications from those who have submitted but who have not yet been awarded their PhD, or are due to submit in the near future, please note that commencement of your appointment will be subject to the confirmation of the award which is expected to be within three months of the initial offer.

　　Further information on the Toxicology Unit can be found at https://www.mrc-tox.cam.ac.uk/

　　Fixed-term: 3 years.

　　Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a health assessment.

　　To apply online for this vacancy and to view further information about the role, please visit:

　　http://www.jobs.cam.ac.uk/job/18919/

　　If you have any queries regarding the application process please contact Rebecca rsh49@mrc-tox.cam.ac.uk

　　Please quote reference PU16847 on your application and in any correspondence about this vacancy.

　　Closing date: 28 October 2018

　　The University values diversity and is committed to equality of opportunity.

　　The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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