Postdoctoral Research Assistant

　　Grade 7, SP29-36 (£32,236 -£39,609)

　　SMED0450

　　Applications are invited for a Postdoctoral researcher to study the regulation of chromosome

　　segregation in the laboratory of Dr Adrian Saurin at the Jacqui Wood Cancer Centre, University of Dundee. This is a CRUK-funded position that is available for 3 years in the first instance.

　　Background

　　Kinases and phosphatases orchestrate a vast array of intracellular responses by toggling phosphorylation sites on and off. Although these enzymes work antagonistically on individual molecules, they also work together to define how these molecules behave collectively in time and space. This “cooperativity” is something we know little about and yet it can determine critical features of a signalling response (1,2). For example, we showed previously how the mitotic checkpoint integrates the activities of two kinases and two phosphatases to generate a localised signal that can turn on and off rapidly (3). This postdoctoral position is to examine the importance of kinase-phosphatase coupling at the kinetochore, and in particular, how dynamic phosphorylation cycles can underlie important signalling behaviours (2,4).

　　For further information about this position please contact Dr Adrian Saurin at a.saurin@dundee.ac.uk. To find out more about the lab please visit www.saurinlab.com.

　　1.      Gelens L, Qian J, Bollen M and Saurin AT. The Importance of Kinase-Phosphatase

　　Integration: Lessons from Mitosis. Trends in Cell Biology. 2017.

　　2.      Gelens L and Saurin AT. Exploring the function of dynamic phosphorylationdephosphorylation cycles. Developmental Cell. 2018.

　　3.      Nijenhuis W, Vallardi G, Teixeira A, Kops GJ, Saurin AT. Negative feedback at

　　kinetochores underlies a responsive spindle checkpoint signal. Nature Cell Biology. 2014.

　　4.      Saurin AT. Kinase and Phosphatase Cross-Talk at the Kinetochore. Front Cell Dev Biol. 2018 Jun 19;6:62

　　Your priorities will include:

　　•       Examine the role that kinetochore phosphatases and kinases play in chromosome segregation.

　　•       Use a wide range of cell biology and biochemical approaches, including quantitative live-cell microscopy (FRET/FLIM/FRAP), which will be combined with mathematical modelling (in collaboration).

　　•       Work exclusively in mammalian cell types, which will be genetically modified using

　　CRISPR/Cas9.

　　Who we’re looking for:

　　•       PhD with an excellent track record and at least one first author publication.

　　•       Experience of working within the mitosis field, using relevant microscopy techniques, and/or using mathematical modelling would be highly advantageous.

　　•       The most important requirement is a highly-motivated and ambitious Postdoctoral researcher with a passion for science. If you lack technical experience but can demonstrate real drive and past success, then please still apply.

　　Closing Date for this post is 11 November 2018.

　　The calibre of research at Dundee is high, with 95 per cent of staff working in areas of national or international excellence. Dundee benefits from a developed network of inter-disciplinary researchers collaborating across various Schools across our community.

　　The diversity of our staff and students helps to make the University of Dundee a UK university

　　of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff support networks for BME and LGBT staff, membership of Athena SWAN and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.

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