招聘簡介：

　　瑞士洛桑大學(xué)生物化學(xué)系Petr Broz教授的實驗室旨在招募一位充滿激情的博士后研究員，加入一個關(guān)于角色的跨學(xué)科項目。

　　'宿主 - 病原體相互作用和免疫中的細(xì)胞死亡'

　　Broz實驗室研究病原體感染或無菌炎癥期間細(xì)胞死亡的作用。該實驗室的一個特別關(guān)注點是pyroptosis，一種由gasdermin家族成員引起的炎癥性細(xì)胞死亡。 Gasdermins是新的成孔蛋白家族，通過蛋白水解切割活化，并使細(xì)胞膜透化以誘導(dǎo)炎癥和細(xì)胞死亡。

　　工作信息

　　預(yù)計開始日期到位：待商定

　　合同期限：1年，可續(xù)訂，最長5年

　　活動率：100％

　　工作場所：Epalinges生物化學(xué)系

　　你的責(zé)任

　　我們正在尋找具有強大分析和實驗技能的創(chuàng)造性和堅定的候選人，并有興趣研究gasdermins在細(xì)胞穩(wěn)態(tài)和疾病中的作用。您將在一個協(xié)作和跨學(xué)科團(tuán)隊工作，解決復(fù)雜的生物問題，并從免疫學(xué)，信號，分子生物學(xué)，微生物學(xué)和生物化學(xué)領(lǐng)域。您將協(xié)調(diào)確定gasdermin激活機制，調(diào)節(jié)及其生理功能的方法，監(jiān)督Msc / PhD學(xué)生并在高度可見的期刊中作為第一作者發(fā)表。關(guān)于細(xì)胞生物學(xué)或細(xì)胞死亡的生物化學(xué)的現(xiàn)有技能將是優(yōu)勢。

　　英文原文：

　　The laboratory of Prof. Petr Broz in the Department of Biochemistry, University of Lausanne, Switzerland seeks to recruit a passionate postdoctoral researcher to join an interdisciplinary project on the role of

　　‘Cell death in host-pathogen interaction and immunity’

　　The Broz lab investigates the role of cell death during pathogen infection or sterile inflammation. A particular focus of the lab is pyroptosis, an inflammatory type of cell death caused by gasdermin family members. Gasdermins are new family of pore-forming proteins that are activated by proteolytic cleavage, and which permeabilize cellular membranes to induce inflammation and cell death.

　　Job information

　　Expected start date in position : to be agreed

　　Contract length : 1 year, renewable, maximum 5 years

　　Activity rate : 100%

　　Workplace : Department of Biochemistry, Epalinges

　　Your responsibilities

　　We are looking for a creative and determined candidate with strong analytical and experimental skills and an interest in studying the role of gasdermins in cellular homeostasis and disease. You will be working in a collaborative and interdisciplinary team that tackles complex biological problems and draws from the fields of immunology, signaling, molecular biology, microbiology and biochemistry. You will coordinate approaches to identify the mechanism of gasdermin activation, regulation and their physiological function, supervise Msc/PhD students and publish as first author in highly visible journals. Existing skills with regard to the cell biology or biochemistry of cell death would be an advantage.

　　Your qualifications

　　Applicants should hold a PhD/MD-PhD in life sciences with a strong background in cell death research, innate immunity or host-pathogen interaction and should have a solid publication record in peer-reviewed journals. Specific qualifications include:

　　o    Excellent communication skills with focus on teamwork, the willingness to co-mentor PhD or master students

　　o    A strong work ethic, scientific rigor

　　o    Ability to work independently and complete task efficiently

　　o    Existing skills with regard to biochemistry, cell biology and immunology will be an advantage

　　o    Excellent proficiency in English

　　What the position offers you

　　We offer a great opportunity in the international, dynamic and vibrant research environment of the Department of Biochemistry at the University of Lausanne. Furthermore, outstanding working conditions at the University of Lausanne, state-of-the-art infrastructure, a stimulating research environment that actively promotes dynamic interactions between scientists and a very competitive salary. This project is supported by an ERC Consolidator grant until 2023. The position is available starting Autumn 2019.

　　Contact for further information

　　Prof. Petr Broz

　　University of Lausanne

　　Department of Biochemistry

　　1066 Epalinges Switzerland

　　petr.broz@unil.ch

　　Your application

　　Applications (in English) should include a cover letter with a statement of research interests and qualifications for the position, complete CV and the names of two academic references.

　　To apply, upload your application on the University job portal (https://www.unil.ch/central/fr/home/menuinst/organisation/emplois.html), or send bt email to petr.broz@unil.ch .

　　For more information of the lab, please visit : https://www.unil.ch/ib/en/home/menuinst/research/broz-petr.html

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