瑞典卡羅林斯卡學院血液學與再生醫(yī)學中心博士后職位

Do you want to contribute to top quality medical research?

We are seeking a highly motivated and ambitious individual to join the research group of Eva Hellström Lindberg as a Postdoctoral Fellow to further elucidate cellular and molecular pathways underlying aberrant stem cell function and ineffective erythropoiesis in myelodysplastic syndromes (MDS). Recent studies from our group on this subject encompass Elvarsdottir, et al., Leukemia 2020, Shiozawa, et al., Blood 2017, Mortera Blanco, et al., Blood 2017, Dimitriou, et al., Oncotarget 2016, Conte, et al., Br J Haematology 2015; Malcovati, et al, Blood 2015, Woll, et al., Cancer Cell 2014, Nikpour, et al. Leukemia 2013, We are exploring MDS pathogenesis along two lines; to understand the competitive advantage of SF3B1 mutated stem cells in the human niche, and to outline the mechanisms behind terminal erythroid failure. The project will take place within the frame of a major collaborative research grant and a large personal grant from the Wallenberg Foundation.

Methods will involve advanced flow cytometry and sorting, DNA and RNA sequencing, single-cell sequencing, advanced cell culture systems, imaging techniques, and functional analyses of stem and progenitor cells including mouse experiments.

The Research group

The research group is based at the Center of Hematology and Regenerative Medicine (HERM), Karolinska Institutet. HERM consists of 16 research groups and approximately 100 people and is a nationally leading and internationally competitive environment for studies of hematopoiesis, blood disorders and the human immune system in the context of malignancy and infectious diseases. The vision is to become one of the leading translational research centers in Europe within this field. The environment offers state-of-the art cell culture, molecular biology, flow cytometry and microscopy facilities. In the http://ki.se/en/medh/eva-hellstrom-lindberg-group, you will be working in an international and interdisciplinary research environment, where collaborative efforts are encouraged.

Duties

You are expected to be a talented and enthusiastic researcher with a strong drive to perform translational research, be instrumental in the elaboration of scientific hypothesis, experimental design, experimentation, data analysis and presentation/publication of results. You must be a good team player but still retain enough independence to explore your results from a conceptual standpoint. You will be responsible for your own academic, research and administrative activities, adapt existing and develop new scientific techniques, test hypotheses and analyze data from a variety of sources.

Besides working on existing lab projects, postdocs are encouraged to start their own new projects that can serve to launch their independent careers in science. Our aim is to provide a supportive environment for development of independent scientists.

Entry requirements

A PhD in Cell or Molecular Biology, Hematopoiesis or related sciences is required (2019 or later). Excellent spoken and written English is a requirement. Applicants should have first author publications in recognized peer-reviewed journals.

The position requires experience with the above described cellular and molecular methodologies but more important is a capacity for scientific thinking, high ambition, and collaborative and communicative skills.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Flemingsberg

Application process

An employment application must contain the following documents in English or Swedish:

·         A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work

·         A complete list of publications

·         A summary of current work (no more than one page)

Welcome to apply at the latest 2020-09-11.

The application is to be submitted through the Varbi recruitment system.

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